• Presented intermittent pain abdomen a/w abdominal distension, nausea since 6 months
• h/o weight loss ~10kg/6m
• 2-3 semisolid to liquid stools, uses laxatives, no blood or mucous
o/s evaluation
Colonoscopy
• Terminal ileal stricture at 5 cm from IC valve, scope not negotiable -? IBD – CD / kochs
• Bx – non specific ileitis, MTB PCR => Negative
MRI enterography
• Long segment ileal thickening with luminal narrowing
• Ileo vescical fistula
• Started on Pentasa and Budez- CR
• patient presented to us with abdominal distension and pain , constipation à treated conservatively , passed flatus, stools not passed
CBC - 10.2/12200/4.9
S.CREATNINE - 1.0
LFT - 0.5/0.1
ESR - 26
cue - Plenty of pus cells => E.COLI
Issues
• Elderly male with comorbidities and moderate LV dysfunction (LVEF 42%)
• Fistuliuzing crohns disease with recurrent SAIO
• Urinary tract infection (preclude BIOLOGICS)
• SURGERY => high risk because of co-morbidities
Excellent comment by Dr. Rajendra. UTI can be treated with prolonged high-potency antibiotics before starting biologics. Also, VEDO & USTE will not have an adverse outcome in UTI. My question is, can we try some form of closing device here?
Fistulizing Crohn's requires biologics.
In view of underlying cardiac issues infliximab is contraindicated.
Safer biologics in this situations are Vedolizumab and Ustekinumab.